The iPLEDGE PROGRAM REMS (Risk Evaluation and Mitigation Strategy) The iPLEDGE PROGRAM REMS is a safety program to manage the risk of isotretinoin’s teratogenicity and to minimize fetal exposure. The REMS is required by the U.S. Food and Drug Administration (FDA) to ensure the benefits of isotretinoin outweigh its risks. Description Isotretinoin is used to treat severe, disfiguring nodular acne. It should be used only after other acne medicines or antibiotics have been tried and have failed to help the acne. Isotretinoin may also be used to treat other skin diseases as determined by your doctor. Isotretinoin must not be used to treat women who are able to bear children unless other forms of treatment have been. Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. [5] Isotretinoin is used off-label to treat basal cell carcinoma and squamous cell carcinoma, although clinical evidence. Accutane (isotretinoin) is a form of vitamin A and is used to treat severe nodular acne. Includes Accutane side effects, interactions and indications. Learn about the side effects of Accutane (isotretinoin), from common to rare, for consumers and healthcare professionals. Accutane (Isotretinoin) capsules are a type of retinoid medication that treats severe acne. It can take time before you see the results of this medication. Everything You Need to Know About Isotretinoin The Essential Info What It Is: Isotretinoin, often known by its brand name Accutane®, is an oral medication approved for severe, scarring acne that is normally prescribed for 15-20 weeks. It is sometimes referred to as the “nuclear option” due to its ability to provide remission of acne … Find patient medical information for Isotretinoin on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Accutane (Isotretinoin) may treat acne, warnings, side effects, dosage, drug interactions, patient labeling, reviews, and related medications including drug comparison and health resources. Learn about Accutane side effects and safety risks such as birth defects, psychiatric side effects and inflammatory bowel disease.